Seabios-tpm is definitely a niche case tool. You would only use it if you needed to add tpm support to a non-uefi operating system
Or wanted to add an option for “legacy support”.
Fwiw, seabios is actually the default bios for kvm/qemu/virt-manager
Since Win11 is the only OS I can think of that requires a TPM I never even noticed the lack. I don’t think Qubes even requires one. 
Oh and on Rome, remember to install the spice drivers:
Have fun